Associations between the increase in the number of hospitalizations for primary myocardial infarction and increased levels of oxide and nitrogen dioxide in the winter period compared to the summer period were revealed. It was found that during the entire observation period the increase in the concentration of nitrogen oxide in 10 % of the MPC increases the number of hospital admissions for MI by 1.4 cases and excess concentration of nitrogen dioxide by 0.9 cases. In winter period the excess of the average concentration of nitrogen oxide by 10 % of the MPC was associated with an increase in the number of hospitalizations by 2.9 cases. Thus, there is a relationship between the frequency of hospitalizations of patients with primary myocardial infarction and environmental pollution (the increase of the concentrations of oxide and nitrogen dioxide, phenol in the air). This pattern is more striking manifestation in winter period