IMMUNE STATUS OF ALBINO RATS UNDER EXPERIMENTAL INFECTION CAUSED BY SALMONELLA CHOLERA SUIS AT SUBACUTE T-2 TOXICOSIS

Modern animal husbandry is faced with ecological problems, caused by micotoxine feed contamination, presence of potentially pathogenic microorganisms (Escherichia, Salmonella, coccal microflora, etc.) and various xenobiotics of physical and chemical nature in the animal environment. Total impact of commercial farm immunopathogenic factors on the animals is of particular concern. Therefore, combination of T-2 toxin and Salmonella cholerae suis impact on the albino rats’ immune status was experimentally studied. The researches made stated that salmonella contamination against the background of subacute T-2 toxin was accompanied by significant changes of gemomorphological and immune statuses. Evident neutrophilia onset in animals was accompanied by IL-1β concentration increase. Insignificant increase of humoral (serum bactericidal activity, SBA) nonspecific immunity was determined by synergistic effect of toxin and infectious agent. Complementary blood serum activity, which was necessary for the increase of organism’s resistance to intoxication, increased in proportion to the toxin and salmonella doses increase.

• Mas’yanov Yu.N.
• Sashnina L.Yu.
• Shakhov A.G.
• Tafintseva I.Yu.
• Vostroilova G.A.

• Искусство. Декоративно-прикладное искусство. Фотография. Музыка. Игры. Спорт

• Естественные науки
• Сельское хозяйство. Лесоводство