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ACE, FTO and VDR polymorphisms are associated with morphological characteristics of the elite rock-climbers

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Section APPLIED ANTHROPOLOGY ACE, FTO AND VDR POLYMORPHISMS ARE ASSOCIATED WITH MORPHOLOGICAL CHARACTERISTICS OF THE ELITE ROCK-CLIMBERS Gaydamakina Alina1 , Bondareva Elvira2 , Baykovskiy Uriy1 , Godina Elena1 Research Institute and Museum of Anthropology, Lomonosov Moscow State University, Moscow, Russia The aim of the study was to examine possible relationships between I/D polymorphism of ACE, T/A poly1Russian State University of Physical Education, Sports, Youth and Tourism, Moscow, Russia 2 morphism of FTO and G/A polymorphism of VDR genes with selected anthropometrical characteristics among 12 (6 males and 6 females) elite rock-climbers, aged from 20 to 30 years. <...> Polymorphisms of these genes are associated with physical capacities (ACE), increased risk of fat accumulation (FTO) and decreased bone mineral density (VDR). <...> Detailed anthropological characteristics of this investigated group are presented in our previous article (Gaydamakina et al., 2013). <...> Genotypes were determined with the minisequencing technique followed by MALDI-TOF detection (Ross et al., 1998). <...> Results: the distribution of the genotype frequencies of all examined genes are not in accordance with the Hardy–Weinberg equilibrium. <...> Each person in the investigated sample carries at least one insertion (I) allele of the ACE gene, which could reveal increased aerobic capacities of the elite rock-climbers. <...> There are no AA genotype carriers of the FTO gene among the investigated athletes. <...> Thus, elite rock-climbers do not have genetically determined risk of an increased fat accumulation. <...> Previously it was shown that peak mineral density is decreasing in the rock-climbers compared with other athletes (Sherk et al., 2010). <...> In the total sample only two persons have GG genotype of the VDR gene, which determines normal bone mineral density. <...> Most of the participants (83%) carry at least one mutant (A) allele, which determines a decreased bone mineral density. <...> The investigation of three molecular-genetic makers ACE, FTO and VDR among the elite rock-climbers has shown the following tendencies: the occurrence of I-allele of the ACE gene, T-allele of the FTO gene and A-allele of the VDR gene. <...> Our results correspond with the investigations by other authors (Djarova et al., 2013; Sherk et al., 2010 <...>
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